Brian Griffin has died on "Family Guy" during Episode 6 of Season 12 titled "Life of Brian" on the long-running animated show. The Seth MacFarlane created show had hinted on a main character being killed off this season. He recently talked to The Hollywood Reporter and said that he was waiting for fans to lose interest on the show as he feels it should have ended a long time ago. Seth said, "I talk to the fans and in a way I’m kind of secretly hoping for them to say we’re done with it. There are plenty of people who say the show is kind of over the hill…but the vast majority go pale in the face when I mention the possibility." RELATED: Brian Griffin Death: ‘Family Guy’ Characters That Should Have Died Instead Of Stewie's Best Friend [POLL]

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Brian was an integral part of the show as he was the Griffin's talking pet dog. Brian died and is now being replaced by a "pooch with attitude" named Vinnie. The new character is voiced by Tony Sirico, best known for starring in "The Sopranos." The pet is replacing Brian who died being run over by a car. Stewie was obviously devastated by what seemed unimaginable and with his time machine broken, the Griffin family could not go back and change the course of events that lead to the death of Brian, a character voiced by creator Seth MacFarlane.

RELATED: Watch ‘Family Guy’ Season 12 Episode 6 Online: Who Will Die Tonight In ‘Life Of Brian’? [VIDEO]

Brian Griffin lived in a world where no one thought it was weird a talking dog existed and he had relationships with actual humans, not other dogs. Brian had a no "bs" personality and he had some of the best lines on the show. Check out some of our favorite quotes and videos down below.

RELATED: Brian Griffin Dies On 'Family Guy': Twitter Lashes Out At Seth MacFarlane With #BringBackBrian

 1. "Lois has gained some weight since you guys stopped having sex. Maybe you should, uh, you know, have some sex"

2. "Hey barkeep, whose leg do you gotta hump to get a dry martini around here?"

3. Bob Barker: Help control the pet population and have your pet spayed or neutered.
Brian: Oh, just die already

4. "The real hero here is God: for blessing me with this nose, and a few other amazing appendages!"

5. Brian: Insert rod support A into slot B.
Peter: That's what...
Brian: If you say "That's what she said" one more time, I swear I'm gonna pop you one

6. "Hey, how about a little less questions and a little more shut the hell up"

7. Meg: Wow, Brian! Have you lost weight? You gotta tell me your secret!
Brian: Here's a hint: Put down the fork!

8. Girl: O Captain my Captain!
Brian: Alright, be the best damn hooker you can be!
Girl #2: O Captain, my Captain!
Brian: In your case, I'd get the money up front

9. I guess you can't judge a Brooke by her cover. [Laughs] You can cut that out right? Oh, and maybe you can cut out when I said junk earlier, the whole Chevy Chase thing. Seems like he's probably the kind of guy that would sue, he's gotta have no money left

10. "I was just watching this special on VH1 about Gwen Stefani. I don't know what a hollaback girl is, all I know is I want her dead."

PHOTO CREDIT: Gold Picture Frame via Shutterstock

1. Stewie beats up Brian over money that he owes him.

2. Brian is dressed as a bee by a group of drunken ladies

3. Brian is annoyed by a crying baby

4. Stewie loved to mess with Brian and here is one of those funny moments.

5. Stewie makes Brian pick up his poop.

6. Brian's biggest love was Jillian, here is a funny bit with both of them

7. Brian also dated Lauren Conrad from "The Hills"

8. Brian throwing up.

9. Brian dating.

10. Brian dating a blind girl.